Related Experiment Video
Updated: Jul 1, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms
Robert J DeRubeis1, Greg J Siegle, Steven D Hollon
1University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. derubeis@psych.upenn.edu
Abstract:
Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies have shown that cognitive therapy is as efficacious as antidepressant medication at treating depression, and it seems to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes.
Related Concept Videos
Cognitive Therapy
Electroconvulsive Therapy
Depression: Overview
Drug Therapy
Antianxiety Medications
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Antidepressant Drugs: MAOIs and Other Agents

