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Exogenous bovine thrombin as a biomarker of exposure and outcome

Sheila M Crean1, Shannon L Michels, Matthew W Reynolds

  • 1Epidemiologist, Health Care Analytics Group, United BioSource Corporation, 101 Station Landing, Medford, MA, USA. sheila.crean@unitedbiosource.com

Expert Review of Molecular Diagnostics
|September 13, 2008
PubMed

Bovine thrombin has been used for more than 60 years as a surgical hemostat and sealant. Rare postsurgical events have been attributed to antibovine thrombin immunoglobulins cross-reacting with human homologs. In a literature review of 37 papers reporting safety outcomes in surgical patients, we extracted each paper for a quantitative measurement of bovine thrombin exposure and coagulopathic outcomes. We found that 59.5% of papers documented the commercial source of bovine thrombin and only 19% provided an estimate of exposure in units. Conventional tests for hypocoagulation were common (86%); however, only 9% of papers confirmed this inhibition as an isolated antibody. In addition, only 9% of papers cited a specific biomarker for thrombosis.

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