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Related Experiment Video

Updated: Jul 1, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Screening rules for growth to detect celiac disease: a case-control simulation study.

Paula van Dommelen1, Floor K Grote, Wilma Oostdijk

  • 1Dept. of Statistics, TNO Quality of life, Leiden, The Netherlands. paula.vandommelen@tno.nl

BMC Pediatrics
|September 13, 2008
PubMed
Summary

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Slowed growth in children with celiac disease (CD) is often assumed but not always effective for diagnosis. Body mass index (BMI) decrease is the most sensitive indicator for symptomatic CD patients.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Growth and Development

Background:

  • Celiac disease (CD) is often associated with impaired growth in children.
  • The diagnostic utility of growth parameters for identifying CD in children remains unclear.
  • This study evaluates the effectiveness of various growth criteria in detecting CD.

Purpose of the Study:

  • To assess the diagnostic efficiency of different growth criteria for identifying children with celiac disease.
  • To compare the effectiveness of length, weight, and Body Mass Index (BMI) in detecting CD.
  • To analyze growth patterns in CD patients with clinical manifestations versus those diagnosed via screening.

Main Methods:

  • A case-control simulation study utilizing longitudinal growth data from birth to 2.5 years.

Related Experiment Videos

Last Updated: Jul 1, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

  • Included three groups of celiac disease patients (n=134) and a reference cohort (n=2,151).
  • Evaluated sensitivity, specificity, and positive predictive value (PPV) for each growth criterion.

    • Main Results:

    • Body Mass Index (BMI) Standard Deviation Score (SDS) decrease was the most effective criterion for CD patients with clinical manifestations.
    • Thirty percent of symptomatic CD children and 2% of controls had a BMI SDS < -1.5 with a decrease of at least -2.5 (PPV=0.85%).
    • Growth criteria did not effectively distinguish screened CD children from the reference group.

    Conclusions:

    • A decrease in BMI SDS is the most sensitive growth parameter for celiac disease children presenting with clinical symptoms.
    • BMI is a superior predictor of CD compared to weight, length, or height in symptomatic children.
    • Celiac disease patients identified through screening exhibit normal growth patterns during early childhood.