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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Observations on the physiological interactions between obesity and asthma.
Katina Nicolacakis1, Mary E Skowronski, Albert J Coreno
1Division of Pulmonary, Critical Care, and Sleep Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 13, 2008
Summary
Asthma and obesity impact lung function differently, with their respiratory effects adding algebraically rather than interacting synergistically. This suggests distinct pathogenic processes rather than shared mechanisms in comorbid patients.
Area of Science:
- Respiratory Medicine
- Pulmonology
- Pathophysiology
Background:
- Asthma and obesity are prevalent conditions affecting respiratory health.
- Understanding shared or distinct pathogenic mechanisms is crucial for managing comorbid asthma and obesity.
Purpose of the Study:
- To investigate whether asthma and obesity share common pathogenic features impacting lung function.
- To determine if the physiological effects of asthma and obesity interact synergistically or add algebraically when present together.
Main Methods:
- Lung function was assessed in normal, asthmatic, obese, and comorbid asthma and obesity groups.
- Measurements included specific conductance, spirometry, lung volumes, and airway responsiveness.
- Six-minute walk tests were conducted in subsets of participants.
Main Results:
- Asthma independently reduced specific conductance and spirometry, increasing airway reactivity and residual volume.
- Obesity independently reduced spirometry, total lung capacity, and functional residual capacity.
- Comorbid asthma and obesity showed additive, not synergistic, effects on lung function, with distinct features remaining unchanged.
Conclusions:
- Asthma and obesity influence the respiratory system through different pathophysiological processes.
- The combined effects of asthma and obesity on lung function are additive, indicating a lack of shared underlying mechanisms.
- These findings suggest distinct therapeutic targets for managing comorbid asthma and obesity.
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