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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
Direct effects of volatile anesthetics on cardiac function
S Gentry-Smetana1, D Redford, D Moore
1Circulatory Sciences Graduate Perfusion Program, The University of Arizona, Tucson, AZ 85724, USA.
Perfusion
|September 16, 2008
Summary
Sevoflurane significantly impairs left ventricular function at lower concentrations than isoflurane during cardiopulmonary bypass (CPB). Lower volatile anesthetic concentrations are crucial for cardiac recovery post-CPB.
Area of Science:
- Anesthesiology
- Cardiovascular Physiology
- Pharmacology
Background:
- Volatile anesthetics are used during cardiopulmonary bypass (CPB) for general anesthesia.
- Their central nervous system effects are understood, but cardiac effects require further definition.
- This study investigates the impact of isoflurane and sevoflurane on left ventricular function during CPB.
Purpose of the Study:
- To determine the effects of isoflurane and sevoflurane on left ventricular function.
- To compare the cardiac impact of these two volatile anesthetics at varying concentrations.
Main Methods:
- C57BL/6 female mice were exposed to isoflurane or sevoflurane (0.5-5%).
- Cardiac function was assessed using transthoracic echocardiography (TTE).
Main Results:
- Sevoflurane reduced left ventricular function at lower concentrations than isoflurane.
- At ≥2% concentrations, sevoflurane significantly decreased cardiac output, ejection fraction, and fractional shortening.
- Sevoflurane also increased end-diastolic and end-systolic volumes.
- Isoflurane caused a less pronounced reduction in left ventricular function compared to sevoflurane.
Conclusions:
- Sevoflurane has a greater negative impact on left ventricular function than isoflurane at clinically relevant concentrations during CPB.
- Lower concentrations of volatile anesthetics are recommended during CPB, particularly during cardiac recovery phases.
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