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Updated: Jul 1, 2026
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Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications
Published on: May 8, 2026
[Study on mass transfer behavior of hemoglobin-based nanocapsule surface]
Yan Sheng1, Yuan Yuan, Xiaoqian Shan
1Engineering Research Center of Biomedical Materials Under Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Summary
Fabricating hemoglobin-based nanocapsules for blood substitutes involves controlling surface structure. Water-soluble solvents like ethyl acetate and acetone modulate nanocapsule pore size, impacting mass transfer.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Chemical Engineering
Context:
- Hemoglobin-based nanocapsules are potential blood substitutes.
- Surface topography significantly affects mass transfer properties.
- Controlling nanostructure is crucial for optimizing performance.
Purpose:
- To investigate the impact of fabrication parameters on the 3D surface structure of hemoglobin-based nanocapsules.
- To understand how surface pore size influences mass transfer.
- To optimize the modified double emulsion method for nanocapsule fabrication.
Summary:
- The modified double emulsion method was employed to create hemoglobin-based nanocapsules.
- Polyethylene glycol (PEG) of varying molecular weights served as probes to analyze surface structure.
- Water-soluble solvents (ethyl acetate, acetone) were found to effectively modulate nanocapsule surface pore size.
- Increased water-soluble solvent ratio initially increased then decreased pore size.
- Higher extra-water volume, longer solvent evaporation, and increased stirring speed enlarged pore size.
- Increased solvent volume and PEG polymer concentration reduced pore size.
Impact:
- Provides insights into tailoring nanocapsule surface morphology for improved blood substitute functionality.
- Establishes correlations between processing conditions and nanostructure, enabling precise control.
- Offers a foundation for developing advanced hemoglobin-based oxygen carriers with optimized mass transfer characteristics.
