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Published on: November 17, 2018

Effect of atorvastatin on LDL & hs-CRP in a selected Thai population

Sarana Boonbaichaiyapruck1, Sayan Cheepudomwit, Pradit Panjavenin

  • 1Ramthibodi Hospital, Mahidol University, Bangkok, Thailand. rasbb@mahidol.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|September 16, 2008
PubMed

Insights

Atorvastatin 20 mg significantly reduced LDL cholesterol and moderately reduced high-sensitivity C-reactive protein (hs-CRP) in a Thai population. Both tested brands of atorvastatin demonstrated similar efficacy and safety profiles.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Low-density lipoprotein (LDL) and high-sensitivity C-reactive protein (hs-CRP) are established risk factors for vascular events.
  • Statin therapy, including atorvastatin, is a key intervention for modifying these risk factors.

Purpose of the Study:

  • To determine baseline hs-CRP levels in a Thai population requiring atorvastatin.
  • To assess the dose-response relationship of atorvastatin on LDL and hs-CRP.
  • To compare the efficacy and safety of different atorvastatin formulations.

Main Methods:

  • A randomized, crossover study involving 110 participants requiring statin therapy.
  • Participants received either Berlin(B)-Atorvastatin or Pfizer(P)-Atorvastatin (20 mg) for 8 weeks, followed by a crossover for another 8 weeks.
  • Comparison of baseline lipid profiles, hs-CRP, liver function tests (LFT), and muscle enzymes at 8 and 16 weeks.

Main Results:

  • Atorvastatin 20 mg resulted in a 32% reduction in total cholesterol (TC) and a 44% reduction in LDL.
  • A moderate 10% reduction in hs-CRP was observed across the study population (p < 0.003).
  • No significant changes were noted in LFT or muscle enzyme levels, indicating a favorable safety profile.

Conclusions:

  • Atorvastatin 20 mg effectively lowers lipid profiles, with a notable impact on LDL cholesterol.
  • The drug demonstrates a moderate effect on hs-CRP levels.
  • The two investigated brands of atorvastatin exhibited comparable safety and efficacy.
Abstract

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