Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

Antiepileptic Drugs: Glutamate Antagonists

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Default Mode Network Resting State Connectivity Derived From Task-Based fMRI: A Validation Study in People With Epilepsy.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2026

Same author

Safety in epilepsy surgery: a multicenter analysis of surgery-related complications and seizure outcome in 1167 cases of mesial temporal lobe epilepsy.

Journal of neurosurgery·2026

Same author

No disconnection syndrome after near-complete callosotomy.

Communications psychology·2025

Same author

There is more diversity than unity within and between the three "cognitively complex lineages".

The Behavioral and brain sciences·2025

Same author

Full interhemispheric integration sustained by a fraction of posterior callosal fibers.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Cultural Considerations in the Context of the I-PACE Model of Addictive Behaviors: Commentary on Lee et al.'s "Applying the Interaction of Person-Affect-Cognition-Execution Model to Addictive Behaviors in East Asian Countries: Feasibility and Considerations".

Journal of the Korean Academy of Child and Adolescent Psychiatry·2025

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Decision making in patients with temporal lobe epilepsy.

Kirsten Labudda¹, Kristina Frigge, Simone Horstmann

¹Department of Physiological Psychology, University of Bielefeld, P.O. Box 100131, 33501 Bielefeld, Germany. kirsten.labudda@uni-bielefeld.de

Neuropsychologia

|September 16, 2008

Summary

Unilateral mesiotemporal lobe epilepsy (TLE) patients show decision-making deficits, particularly on the Iowa Gambling Task, linked to hippocampal damage. These impairments in feedback-based decision-making occur even without amygdala abnormalities.

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Related Experiment Videos

Last Updated: Jul 1, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Area of Science:

Neuroscience
Cognitive Psychology
Clinical Neurology

Background:

The mesiotemporal lobe, including the amygdala and hippocampus, is crucial for decision-making, particularly involving emotional feedback.
Previous research suggests feedback processing and executive functions are vital for decision-making under risk.

Purpose of the Study:

To investigate if unilateral mesiotemporal lobe damage in epilepsy patients alters decision-making based on feedback and under risk.
To examine the specific roles of the hippocampus and amygdala in these decision-making processes.

Main Methods:

Preoperative assessment of 20 unilateral mesiotemporal lobe epilepsy (TLE) patients and 20 healthy controls using the Iowa Gambling Task and Game of Dice Task.
Neuropsychological testing was conducted to evaluate executive functions.

Main Results:

TLE patients performed normally on risk-based decision-making (Game of Dice Task) but showed deficits in feedback-based decision-making (Iowa Gambling Task).
A subgroup of TLE patients preferring disadvantageous choices exhibited poorer executive function and earlier seizure onset.
Decision-making deficits were observed even in patients with hippocampal lesions but no amygdala abnormalities.

Conclusions:

Presurgical TLE patients can exhibit selective decision-making deficits, primarily in feedback processing.
These deficits may stem from hippocampal damage alone, independent of amygdala involvement.
Findings highlight the hippocampus's role in feedback-based decision-making and its potential impairment in TLE.