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Updated: Feb 22, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Default Mode Network Resting State Connectivity Derived From Task-Based fMRI: A Validation Study in People With

Lea Wemheuer1, Anna Doll2,3, Martin Wegrzyn3

  • 1Medical School OWL, Clinical Neuropsychology and Epilepsy Research, Bielefeld University, Bielefeld, Germany.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|February 21, 2026
PubMed
Summary
This summary is machine-generated.

The intermittent resting state fMRI method effectively measures functional connectivity in epilepsy patients, yielding results comparable to standard resting state fMRI. This approach offers an efficient way to study brain networks in clinical populations.

Keywords:
default mode networkepilepsyfunctional connectivityfunctional neuroimagingresting statetask‐based fMRI

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Area of Science:

  • Neuroimaging
  • Clinical Neuroscience
  • Functional MRI

Background:

  • Resting state functional MRI (fMRI) is used to measure functional connectivity.
  • This method is validated in healthy individuals but not clinical cohorts.
  • Epilepsy alters functional connectivity in resting state networks, but data quality is unclear.

Purpose of the Study:

  • To validate the intermittent resting state fMRI method in people with epilepsy.
  • To compare functional connectivity derived from standard resting state fMRI and clinical language fMRI rest periods.

Main Methods:

  • Compared functional connectivity from standard resting state and intermittent resting state fMRI in 92 epilepsy patients.
  • Analyzed topography, within-network connectivity, and group comparisons.
  • Utilized independent component analyses (ICAs), similarity, ROI-to-ROI, and seed-based analyses.

Main Results:

  • Similar default mode network (DMN) and somatomotor network (SMN) topography derived from both methods.
  • Comparable within-network connectivity results.
  • Analogous seed-based analyses for hippocampal connectivity, with minor restrictions in right hippocampal connectivity.

Conclusions:

  • Intermittent resting state fMRI yields highly similar functional connectivity results to standard resting state fMRI in epilepsy patients.
  • This method is an efficient approach for studying functional connectivity in clinical cohorts.
  • No additional resting state fMRI is needed, saving time and resources.