Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

Homeostatic Imbalances in Body Temperature

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

Methods of reducing fever

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Durable response to nivolumab in combination with regional hyperthermia in a patient with PD-L1-negative metastatic head and neck squamous cell carcinoma.

Cancer immunology, immunotherapy : CII·2025

Same author

Regional hyperthermia for soft tissue sarcoma - a survey on current practice, controversies and consensus among 12 European centers.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2024

Same author

Regional hyperthermia with cisplatin added to gemcitabine versus gemcitabine in patients with resected pancreatic ductal adenocarcinoma: The HEAT randomised clinical trial.

European journal of cancer (Oxford, England : 1990)·2023

Same author

VISTA in Soft Tissue Sarcomas: A Perspective for Immunotherapy?

Cancers·2022

Same author

Immune infiltrates in patients with localised high-risk soft tissue sarcoma treated with neoadjuvant chemotherapy without or with regional hyperthermia: A translational research program of the EORTC 62961-ESHO 95 randomised clinical trial.

European journal of cancer (Oxford, England : 1990)·2021

Same author

Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer.

Cancers·2021

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Hyperthermia adds to chemotherapy.

Rolf D Issels¹

¹University of Munich, Campus Grosshadern, Medical Clinic III, Munich, Germany. rolf.issels@med.uni-muenchen.de

European Journal of Cancer (Oxford, England : 1990)

|September 16, 2008

Summary

Combining hyperthermia with chemotherapy offers significant benefits for cancer treatment. This approach enhances drug effectiveness and stimulates the immune system, proving its value in clinical trials.

Area of Science:

Oncology
Medical Physics
Immunology

Background:

Hyperthermia, the therapeutic use of heat, exhibits pleiotropic effects beneficial for cancer treatment.
Preclinical studies highlight the critical role of thermal dose in achieving synergistic effects with chemotherapy.
Hyperthermia can induce cellular death and necrosis without increasing oncogenic potential, while activating the host immune system via stress responses.

Purpose of the Study:

To evaluate the efficacy of combining hyperthermia with chemotherapy as a cancer treatment modality.
To explore the mechanisms by which hyperthermia enhances chemotherapy's anti-cancer effects.
To emphasize the clinical value and potential for broader application of regional hyperthermia (RHT) and hyperthermic perfusion.

Main Methods:

More Related Videos

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Published on: December 1, 2023

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Jul 1, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Published on: December 1, 2023

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Review of preclinical research on thermal dose and synergistic effects.
Analysis of randomized clinical trials investigating hyperthermia combined with chemotherapy.
Examination of studies on regional hyperthermia (RHT) and hyperthermic perfusion in specific clinical settings.

Main Results:

Positive results from randomized trials have established hyperthermia and chemotherapy as a novel clinical cancer treatment.
Hyperthermia targets chemotherapy's action within the tumor, minimizing systemic toxicity.
Regional hyperthermia (RHT) and hyperthermic perfusion have demonstrated value in specific settings.

Conclusions:

Hyperthermia in combination with chemotherapy is a validated and effective clinical modality for cancer treatment.
Further investigation and broader application of RHT and hyperthermic perfusion in various malignancies are warranted.
Establishing specialized centers for hyperthermia in oncology across Europe is recommended to advance research and clinical practice.