Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lipopolysaccharide-induced murine lung injury results in long-term pulmonary changes and downregulation of angiogenic pathways.

Scientific reports·2022

Same author

Class II HLA Eplet Mismatch Is a Risk Factor for De Novo Donor-Specific Antibody Development and Antibody-mediated Rejection in Kidney Transplantation Recipients.

Transplantation proceedings·2018

Same author

Severe Phlebitis Accompanying Vascular Rejection Type Acute T Cell-Mediated Rejection in Renal Transplantation.

Transplantation proceedings·2018

Same author

Incidence and risk factors for colorectal neoplasia in patients with oral squamous cell carcinoma.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2014

Same author

The impact of donor factors on early graft function in kidney transplantation from donation after cardiac death.

Transplantation proceedings·2014

Same author

Excellent results of immunocomplex capture fluorescence analysis-I for cross-match test in renal transplantation.

Transplantation proceedings·2014

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Malignancy following kidney transplantation.

N Arichi¹, H Kishikawa, K Nishimura

¹Department of Urology and Renal Transplantation Center, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan. naokoarichi2002@yahoo.co.jp

Transplantation Proceedings

|September 16, 2008

Summary

Kidney transplant recipients face a rising risk of various cancers, particularly in later decades post-transplant. Early detection and treatment of cancers like skin cancer improve patient survival rates.

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Related Experiment Videos

Last Updated: Jul 1, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

Nephrology
Oncology
Transplant Surgery

Background:

Solid organ transplantation, particularly kidney transplantation, significantly increases long-term cancer risk.
Understanding the incidence, types, and survival outcomes of malignancies post-kidney transplant is crucial for patient management.

Purpose of the Study:

To determine the incidence and types of malignancies in kidney transplant recipients.
To analyze the impact of malignancy on patient survival.
To investigate the association between immunosuppressive therapy and cancer development.

Main Methods:

Retrospective cohort study of 429 kidney transplant recipients (1973-2007).
Analysis of cumulative incidence of malignancy over time.
Comparison of survival rates between patients with and without malignancy.
Evaluation of specific cancer types and treatment outcomes.
Assessment of immunosuppression regimens, including tacrolimus.

Main Results:

13.3% of patients developed 62 malignancies.
Cancer incidence increased significantly in the second and third post-transplant decades.
Cumulative incidence reached 25.6% by 25 years post-transplant.
Patients without malignancy had significantly better survival.
Common cancers included skin, renal cell, hepatocellular, PTLD, uterine, and colorectal.
5-year survival post-treatment was better for skin and native kidney cancers.
Tacrolimus-based immunosuppression was associated with a higher incidence of malignancy.

Conclusions:

Long-term kidney transplant recipients have a substantial risk of developing various cancers.
Malignancy significantly impacts long-term survival after kidney transplantation.
Immunosuppressive strategies, particularly tacrolimus-based regimens, warrant further investigation regarding their oncogenic potential.