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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...

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Related Experiment Video

Updated: Jul 1, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Stigmatisation in onychomycosis patients: a population-based study.

Jacek C Szepietowski1, Adam Reich,

  • 1Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. jszepiet@derm.am.wroc.pl

Mycoses
|September 17, 2008
PubMed
Summary

Onychomycosis significantly impacts patients

Area of Science:

  • Dermatology
  • Psychology
  • Public Health

Background:

  • Onychomycosis, a fungal nail infection, often leads to psychosocial distress comparable to other dermatological conditions.
  • Understanding the extent of stigmatization and its impact on patients' quality of life is crucial for comprehensive care.

Purpose of the Study:

  • To assess the level of stigmatization experienced by individuals with onychomycosis.
  • To evaluate the effectiveness of antifungal therapy in mitigating these feelings of stigmatization.

Main Methods:

  • A prospective study involving 1684 patients diagnosed with onychomycosis.
  • Stigmatization levels were measured using a questionnaire at baseline and post-antifungal treatment.
  • Analysis considered factors like gender, age, education, infection type, duration, and nail involvement.

Related Experiment Videos

Last Updated: Jul 1, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Main Results:

  • Patients with onychomycosis reported significant levels of stigmatization.
  • Fingernail involvement, female gender, and younger age were associated with higher stigmatization.
  • Antifungal therapy led to a substantial reduction (approx. 60%) in stigmatization.

Conclusions:

  • Onychomycosis is associated with considerable psychosocial burden and stigmatization.
  • Fingernail onychomycosis particularly exacerbates feelings of stigma.
  • Effective antifungal treatment can significantly alleviate the stigmatization experienced by patients.