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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jul 1, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Lupus erythematosus panniculitis.

Javier Fraga1, Amaro García-Díez

  • 1Department of Pathology, Hospital Universitario de La Princesa, Diego de Leon 62, 28006 Madrid, Spain. jfraga.hlpr@salud.madrid.org

Dermatologic Clinics
|September 17, 2008
PubMed
Summary

Lupus erythematosus panniculitis is a rare form of lupus affecting subcutaneous fat, presenting unique clinical and histopathologic features. Accurate diagnosis, especially differentiating it from T-cell lymphoma, is crucial.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Lupus erythematosus panniculitis (LEP) is an uncommon variant of lupus erythematosus.
  • It specifically involves the subcutaneous fat, presenting distinct clinical and histopathological characteristics.
  • LEP can occur alongside discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE), or as the sole manifestation of lupus erythematosus.

Purpose of the Study:

  • To review the key clinicopathologic features of lupus erythematosus panniculitis.
  • To discuss the diagnostic challenges, particularly differentiating from subcutaneous panniculitis-like T-cell lymphoma.
  • To outline current treatment strategies for lupus erythematosus panniculitis.

Main Methods:

  • Review of clinical presentations and histopathological findings in lupus erythematosus panniculitis.

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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

  • Analysis of differential diagnostic considerations, emphasizing histopathology.
  • Synthesis of treatment approaches based on existing literature.

    • Main Results:

    • Lupus erythematosus panniculitis is characterized by a predominantly lobular panniculitis on histopathology.
    • Diagnosis can be challenging, especially when it is the only sign of lupus erythematosus.
    • Distinguishing LEP from subcutaneous panniculitis-like T-cell lymphoma requires careful histopathologic evaluation.

    Conclusions:

    • Lupus erythematosus panniculitis requires thorough clinicopathologic assessment for accurate diagnosis.
    • Histopathological features are critical for differentiating LEP from other conditions, including T-cell lymphoma.
    • Understanding these features guides appropriate management and treatment of lupus erythematosus panniculitis.