Related Experiment Video
Updated: Sep 28, 2025
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
2.1K
Cutaneous vascular calcification. Perieccrine calcification as a diagnostic key for calciphylaxis
Alejandra Reolid1, María Martínez-Palazuelo1, Pedro Rodríguez-Jiménez1
1Dermatology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain.
Journal of Cutaneous Pathology
|March 31, 2022
Summary
Perieccrine calcification and concentric calcification patterns may help distinguish classic calciphylaxis (CPX) from incidental cutaneous vascular calcification (CVC). These findings aid in diagnosing CPX, especially when pseudoxanthoma elasticum-like changes are present.
Area of Science:
- Dermatology
- Pathology
- Nephrology
Background:
- Differentiating classic calciphylaxis (CPX) from incidental cutaneous vascular calcification (CVC) is challenging.
- Establishing clear discriminative criteria for CPX is an ongoing clinical need.
Purpose of the Study:
- To identify clinicopathological features distinguishing classic CPX from CVC as an epiphenomenon.
- To evaluate the diagnostic utility of perieccrine calcification and pseudoxanthoma elasticum (PXE)-like changes in CPX.
Main Methods:
- Retrospective observational cohort study of 66 patients with CVC.
- Analysis of clinicopathological parameters, including lesion characteristics, laboratory findings, and histopathology.
- Evaluation of perieccrine calcification and PXE-like changes.
Main Results:
- The CPX group exhibited higher rates of renal failure, hypertension, painful lesions, and mortality.
- Histopathology revealed more affected vessels per field with subintimal concentric calcification and exclusive perieccrine calcification in the CPX group.
- PXE-like changes were more frequent in CPX but also present in the epiphenomenon group.
Conclusions:
- Perieccrine calcification and concentric calcification patterns in multiple vessels are potential diagnostic markers for CPX.
- PXE-like changes, while not exclusive, may suggest a diagnosis of CPX.
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
142
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
142
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
44
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
44
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
50
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
50
01:27Assessment of the Cardiovascular System III: Palpation
531
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
531
01:25Endocarditis II: Clinical Features of Infective Endocarditis
35
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
35
01:20Imaging Studies for Cardiovascular System III: X-Ray
307
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
307