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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Cold panniculitis.

Alicia Quesada-Cortés1, Lucía Campos-Muñoz, Rosa M Díaz-Díaz

  • 1Department of Dermatology, Hospital Universitario La Paz, Universidad Autónoma, Paseo La Castellana, No. 261, 28046 Madrid, Spain. aliciaqc@hotmail.com

Dermatologic Clinics
|September 17, 2008
PubMed
Summary

Cold panniculitis, an inflammatory condition affecting subcutaneous fat, occurs after cold exposure. Histopathology reveals lobular inflammation with lymphocytes and histiocytes, primarily at the dermal-subcutaneous junction.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Cold panniculitis is a condition affecting subcutaneous fat, typically seen in children and young women.
  • It is triggered by exposure to cold temperatures.

Purpose of the Study:

  • To describe the histopathological features of cold panniculitis.
  • To outline the differential diagnosis for this condition.

Main Methods:

  • Histopathological examination of affected tissue.
  • Review of clinical presentation and differential diagnoses.

Main Results:

  • Histopathology shows predominantly lobular panniculitis with lymphocytic and histiocytic infiltrate within fat lobules.
  • Dermal infiltrate consists mainly of lymphocytes, without vasculitis, with inflammation most severe at the dermal-subcutaneous junction.

Conclusions:

  • Cold panniculitis presents characteristic histopathological findings.
  • Distinguishing cold panniculitis from other subcutaneous conditions like neonatal fat necrosis and frostbite is crucial.