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Related Experiment Video

Updated: Jul 1, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
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Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

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Small-animal SPECT and SPECT/CT: important tools for preclinical investigation.

Benjamin L Franc1, Paul D Acton, Carina Mari

  • 1Department of Radiology, Center for Molecular and Functional Imaging, University of California, San Francisco, California, USA. francbl@radiological.com

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 17, 2008
PubMed
Summary

Small-animal SPECT and SPECT/CT imaging advances molecular insights into disease and drug development. These high-resolution nuclear imaging techniques offer improved sensitivity, resolution, and quantification for preclinical research.

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Area of Science:

  • Nuclear medicine
  • Biomedical imaging
  • Preclinical research

Background:

  • Dynamic biologic processes require advanced imaging in small-animal disease models.
  • High-resolution nuclear imaging clarifies molecular interactions and therapeutic responses.
  • Single-photon emission computed tomography (SPECT) offers 3D distribution of radionuclides.

Purpose of the Study:

  • To review the development and applications of small-animal SPECT and SPECT/CT systems.
  • To highlight advancements in nuclear imaging for disease research and drug development.
  • To identify ongoing challenges and future directions in small-animal SPECT imaging.

Main Methods:

  • Development of dedicated small-animal SPECT and SPECT/CT systems.
  • Integration of SPECT with computed tomography (CT) for anatomical context and quantitative accuracy.
  • Advancements in camera sensitivity, spatial resolution, and image reconstruction.

Main Results:

  • Significant progress in dedicated small-animal SPECT and SPECT/CT system development.
  • Demonstrated utility in assessing molecular interactions, drug efficacy, and therapeutic monitoring.
  • Enhanced anatomical localization and quantitative accuracy through SPECT/CT integration.

Conclusions:

  • Small-animal SPECT and SPECT/CT are crucial tools for studying dynamic biologic processes.
  • Continued innovation is needed to overcome limitations in sensitivity, resolution, and quantification.
  • These modalities are driving investment in education, research, and development across multiple medical fields.