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Related Experiment Video

Updated: May 20, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
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Localization of sentinel lymph nodes using augmented-reality system: a cadaveric feasibility study.

Heying Duan1, Yue Yang2, Wally L Niu2

  • 1Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Stanford University, 300 Pasteur Drive, H2200, Stanford, CA, 94305, USA.

European Journal of Nuclear Medicine and Molecular Imaging
|March 24, 2025
PubMed
Summary

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Markerless augmented reality registration for surgical guidance: a multi-anatomy clinical accuracy study.

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Augmented reality (AR) precisely locates sentinel lymph nodes (SLNs) for melanoma staging, significantly reducing localization errors and surgical time compared to traditional methods.

Area of Science:

  • Medical Imaging
  • Surgical Technology
  • Oncology

Background:

  • Sentinel lymph node biopsy (SLNB) is crucial for melanoma staging.
  • Current pre-surgical imaging (SPECT/CT) and intraoperative tools offer limited precision for SLN localization.

Purpose of the Study:

  • To evaluate the accuracy and efficiency of an augmented reality (AR) system for precise SLN localization and extraction.
  • To compare AR-guided localization with standard manual methods.

Main Methods:

  • An AR system projected virtual 3D renderings from PET/MRI scans onto cadavers.
  • The system utilized HoloLens 2 and custom software for visualization.
  • Surgical procedures were performed using standard, AR, and AR with head movement compensation techniques.
Keywords:
Augmented realityHead and neck melanomaMixed realityPET/MRISentinel lymph node

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Main Results:

  • The AR system achieved a mean surface localization error of 2.5 mm and depth error of 2.3 mm.
  • AR significantly reduced localization errors compared to manual marking (2.5 mm vs. 18.6 mm).
  • Task completion time was reduced by 74% with the AR system.

Conclusions:

  • The AR system offers high accuracy and efficiency for SLN localization.
  • Integrating head-movement compensation and 3D visualization enhances precision.
  • This technology has the potential to reduce operating room time in SLNB procedures.