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In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
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Published on: October 20, 2013

Pigmented villonodular synovitis: radiologic-pathologic correlation.

Mark D Murphey1, John H Rhee, Rachel B Lewis

  • 1Department of Radiologic Pathology, Armed Forces Institute of Pathology, 16th St NW, Washington, DC 20306, USA. murphey@afip.osd.mil

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|September 17, 2008
PubMed
Summary
This summary is machine-generated.

Pigmented villonodular synovitis (PVNS) is a rare benign tumor affecting joints, bursae, or tendon sheaths. MR imaging, particularly T2-weighting and gradient-echo sequences, offers near-pathognomonic findings for diagnosis and treatment planning.

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07:15

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Published on: October 20, 2013

Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Background:

  • Pigmented villonodular synovitis (PVNS) is an uncommon benign neoplastic process.
  • It can manifest as diffuse or focal synovitis (PVNS), pigmented villonodular bursitis (PVNB), or pigmented villonodular tenosynovitis (PVNTS).
  • PVNTS, also known as giant cell tumor of the tendon sheath (GCTTS), is the most common form.

Purpose of the Study:

  • To describe the diverse presentations of PVNS, PVNB, and PVNTS.
  • To highlight the diagnostic utility of various imaging modalities, especially MRI.
  • To emphasize the importance of accurate radiologic assessment for guiding treatment and surgical resection.

Main Methods:

  • Review of pathologic and radiologic features of PVNS, PVNB, and PVNTS.
  • Analysis of radiographic findings including joint effusions, soft-tissue masses, and bone erosion.
  • Detailed evaluation of cross-sectional imaging, focusing on MRI characteristics such as T2-weighted signal intensity and gradient-echo blooming artifact.

Main Results:

  • Radiographs show nonspecific findings; bone erosion is common in hip involvement.
  • Cross-sectional imaging aids in differentiating PVNS, PVNB, and PVNTS based on location and extent.
  • MRI findings, specifically low T2 signal and hemosiderin blooming artifact, are nearly pathognomonic.

Conclusions:

  • Recognizing the distinct radiologic appearances of PVNS subtypes is crucial for accurate diagnosis.
  • MRI is optimal for assessing lesion extent, guiding treatment, and achieving complete surgical resection.
  • Distinguishing PVNS from malignant transformation requires careful pathological and radiological evaluation.