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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Updated: Jun 30, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Sarcoidosis: a primer.

John Colangelo1, Donna L Wright

  • 1Radiologic Sciences Department, Midwestern State University, Wichita Falls, TX, USA.

Radiologic Technology
|September 18, 2008
PubMed
Summary
This summary is machine-generated.

Sarcoidosis is a complex, variable disease affecting multiple organs with granulomas. Understanding its clinical and radiologic features is crucial for diagnosis and management, with ongoing research into its cancer links.

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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Area of Science:

  • Internal Medicine
  • Pathology
  • Radiology

Background:

  • Sarcoidosis is a multisystem inflammatory disease characterized by non-caseating granulomas.
  • Its clinical presentation and organ involvement exhibit significant heterogeneity.
  • Disease course ranges from spontaneous resolution to chronic, progressive organ damage.

Purpose of the Study:

  • To review the diverse clinical and radiologic manifestations of sarcoidosis.
  • To emphasize the importance of recognizing sarcoidosis features for accurate diagnosis and management.
  • To highlight the need for further investigation into the association between sarcoidosis and malignancy.

Main Methods:

  • Comprehensive literature review of clinical and radiologic studies on sarcoidosis.
  • Analysis of diagnostic criteria and management strategies.
  • Examination of epidemiological data regarding sarcoidosis and cancer.

Main Results:

  • Sarcoidosis can affect virtually any organ, leading to varied symptoms and imaging findings.
  • Early recognition of characteristic clinical and radiologic patterns aids diagnosis.
  • The relationship between sarcoidosis and the risk of developing malignant neoplasms requires further elucidation.

Conclusions:

  • Effective diagnosis and management of sarcoidosis depend on a thorough understanding of its varied presentations.
  • Continued research is essential to clarify the potential link between sarcoidosis and cancer.
  • Multidisciplinary collaboration is key for optimal patient care in sarcoidosis.