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Related Experiment Video

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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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Published on: November 16, 2016

Soy isoflavones and immunity.

Tohru Sakai1, Mari Kogiso

  • 1Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School, Tokushima, Japan.

The Journal of Medical Investigation : JMI
|September 18, 2008
PubMed
Summary

Soy isoflavone genistein impacts immune responses, suppressing some while enhancing others. This immune cell-dependent action suggests potential therapeutic roles in conditions like allergic inflammation.

Area of Science:

  • Immunology
  • Nutritional Science
  • Pharmacology

Background:

  • Soy isoflavones, particularly genistein, are consumed at high levels in Asian diets.
  • Genistein exhibits structural similarity to 17beta-estradiol (E2), suggesting potential hormonal activity.
  • Emerging evidence links soy isoflavones to benefits in metabolic, oncological, and cardiovascular diseases.

Purpose of the Study:

  • To review current research on the immunomodulatory effects of the soy isoflavone genistein.
  • To elucidate the complex and cell-dependent mechanisms by which genistein influences immune responses.
  • To explore the therapeutic potential of genistein in immune-related conditions.

Main Methods:

  • Review of in vivo and in vitro studies investigating genistein's impact on immune cells.

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  • Analysis of genistein's effects on antigen-specific immune responses, lymphocyte proliferation, and cytotoxic activities.
  • Examination of genistein's influence on cytokine production and inflammatory responses.

    • Main Results:

    • Genistein demonstrates differential effects on immune cells, suppressing some responses while augmenting others.
    • The compound inhibits antigen-specific immune responses and lymphocyte proliferation in vitro.
    • Conversely, genistein enhances NK and cytotoxic T cell activity and T cell cytokine production.
    • Genistein has shown efficacy in inhibiting allergic inflammatory responses in animal models.

    Conclusions:

    • Genistein's immunomodulatory effects are highly dependent on the specific immune cell type involved.
    • Its dual action on the immune system presents a unique pharmacological profile.
    • Genistein holds promise as a therapeutic agent for immune-related diseases, including allergic inflammation.