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Updated: Jun 30, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Drug-induced lupus erythematosus
Camilla Dalle Vedove1, Micol Del Giglio, Donatella Schena
1Section of Dermatology and Venereology, Department of Biomedical and Surgical Sciences, University of Verona, Piazzale A. Stefani 1, 37126, Verona, Italy.
Archives of Dermatological Research
|September 18, 2008
Summary
Drug-induced lupus erythematosus (DILE) is a lupus-like illness triggered by medications, resolving upon drug cessation. Anti-TNFalpha agents present unique DILE features compared to classic forms, requiring careful diagnosis.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Drug-induced lupus erythematosus (DILE) mimics idiopathic lupus but resolves after drug withdrawal.
- Diagnostic criteria for DILE are lacking, and its mechanisms remain unclear.
- DILE presents in systemic (SLE), subacute cutaneous (SCLE), and chronic cutaneous (CCLE) forms.
Purpose of the Study:
- To review the characteristics of drug-induced lupus erythematosus (DILE).
- To compare DILE induced by anti-TNFalpha agents with classic DILE.
- To highlight diagnostic challenges and features of DILE.
Main Methods:
- Literature review of drug-induced lupus erythematosus (DILE) cases.
- Comparative analysis of DILE associated with anti-TNFalpha agents versus traditional triggers.
- Summary of clinical and serological findings.
Main Results:
- Classic DILE is associated with hydralazine, procainamide, and isoniazid, often showing anti-histone antibodies.
- Drug-induced SCLE is linked to calcium channel blockers, ACE inhibitors, and others.
- DILE from anti-TNFalpha agents presents distinct features, including higher rash incidence, potential renal involvement, and different antibody profiles (e.g., anti-dsDNA, anti-ENA).
Conclusions:
- DILE diagnosis relies on temporal association with drug exposure and symptom resolution upon withdrawal.
- Anti-TNFalpha-induced DILE exhibits unique clinical and serological characteristics compared to classic DILE.
- Recognizing DILE in patients on anti-TNFalpha therapy is crucial due to overlapping symptoms with underlying conditions.
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