Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Pore or not a Pore? Understanding Pore Size Distributions of Non-Graphitic Carbon and Atomically-Dispersed M-N-C Materials.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A Comparison of Biological Therapies vs Traditional Immunosuppressant in the Management of Inflammatory Bowel Diseases: A Narrative Review.

Journal of community hospital internal medicine perspectives·2026
Same author

Exosomal miRNAs versus circulating tumor DNA: diagnostic accuracy for early detection of recurrence post-radical prostatectomy: A narrative review.

Medicine·2025
Same author

Designing Co-N/C Cathode Catalysts with Dense Atomic Cobalt Sites for Enhanced PEMFC Performance.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Nickel Nanocluster-Stabilized Unsaturated Ni-N<sub>3</sub> Atomic Sites for Efficient CO<sub>2</sub>-to-CO Electrolysis at Industrial-Level Current.

Angewandte Chemie (International ed. in English)·2025
Same author

Assessment of the understanding and awareness of bioethics among healthcare professionals in all public and private hospitals of Haripur district, Pakistan: a multicentre cross-sectional study.

BMJ open·2024
Same journal

Cerebral Cysticercosis Manifesting 20 Years after Primary Cutaneous Disease.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
Same journal

Primary Leiomyosarcoma of the Pancreas with Liver Metastasis: Challenges and Possible Treatment Approaches.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
Same journal

Rising Trend of Cancer in Pakistan: An Urgent Call for Action.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
Same journal

Conflicting Roles of Urotensin II in Chronic Kidney Disease: Insights from Clinical and Mechanistic Studies.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
Same journal

Invasive Fibromatosis Adjacent to the Twelfth Thoracic Vertebra and Involving the Oesophagus.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
Same journal

Low-Density Lipoprotein Cholesterol Rebound: Rethinking Appendectomy in Coronary Heart Disease.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2026

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
05:17

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Paroxysmal nocturnal hemoglobinuria.

Asad Mehmood1, Muhammad Ashraf Sharif, Badar Murtaza

  • 1Department of Department of Medicine, Combined Military Hospital, Bahawalnagar, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|September 19, 2008
PubMed
Summary
This summary is machine-generated.

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare hemolytic disorder. This case study highlights a patient diagnosed with PNH, emphasizing diagnostic markers and corticosteroid treatment for hemolysis.

More Related Videos

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore
09:15

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Published on: January 21, 2020

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Related Experiment Videos

Last Updated: Jun 30, 2026

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
05:17

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

Published on: July 28, 2016

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore
09:15

Induction of Eryptosis in Red Blood Cells Using a Calcium Ionophore

Published on: January 21, 2020

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Area of Science:

  • Hematology
  • Genetics

Background:

  • Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired hemolytic anemia.
  • It arises from clonal expansion of hematopoietic stem cells with genetic mutations.
  • PNH is characterized by complement-mediated intravascular hemolysis.

Observation:

  • A 30-year-old male presented with transfusion-dependent anemia and dark urine.
  • Diagnostic workup revealed negative Coombs test, elevated LDH, hemosiderinuria, and CD59-deficient RBCs on flow cytometry.
  • These findings confirmed PNH in the patient.

Findings:

  • The patient exhibited classic symptoms and laboratory findings consistent with PNH.
  • Flow cytometry confirmed a significant percentage of CD59-deficient red blood cells, a hallmark of PNH.
  • The diagnostic process involved a combination of clinical presentation and specific laboratory tests.

Implications:

  • Accurate diagnosis of PNH is crucial for appropriate management.
  • Treatment strategies, such as corticosteroids, should be tailored to the underlying cause of anemia (hemolysis vs. impaired erythropoiesis).
  • This case underscores the importance of recognizing PNH symptoms and utilizing advanced diagnostics like flow cytometry.