Related Experiment Videos
Epidermal calmodulin levels in psoriasis before & after therapy.
1Department of Dermatology, Postgraduate Institute of Medical Education & Research, Chandigarh.
The Indian Journal of Medical Research
|April 1, 1991
Summary
Psoriasis treatment with dithranol or methotrexate significantly reduces epidermal calmodulin levels in both affected and unaffected skin. This finding highlights calmodulin
Area of Science:
- Dermatology and Biochemistry
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Calmodulin (CaM) is a calcium-binding protein involved in cellular signaling.
Purpose of the Study:
- To investigate the role of epidermal calmodulin in psoriasis.
- To assess changes in calmodulin levels following treatment.
Main Methods:
- Epidermal calmodulin levels were measured in 26 psoriasis patients.
- Patients received either topical dithranol or oral methotrexate.
- Measurements were taken before and after treatment.
Main Results:
- Involved psoriatic skin showed higher baseline calmodulin levels than uninvolved skin.
- Successful treatment, regardless of modality, led to a significant reduction in epidermal calmodulin.
- Calmodulin levels in uninvolved skin also decreased post-treatment.
Conclusions:
- Epidermal calmodulin levels are altered in psoriasis.
- Reducing calmodulin activity may be a therapeutic target for psoriasis.
- Calmodulin changes occur in both lesional and non-lesional skin.