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High-strength resorbable brushite bone cement with controlled drug-releasing capabilities
M P Hofmann1, A R Mohammed, Y Perrie
1Biomaterials Unit, School of Dentistry, University of Birmingham, St. Chad's Queensway, Birmingham B4 6NN, UK. m.p.hofmann@bham.ac.uk
Acta Biomaterialia
|September 19, 2008
Summary
This study produced a brushite ceramic with significantly reduced porosity, enhancing mechanical strength and controlling antibiotic release. Near-zero porosity brushite cement minimizes burst release of incorporated antibiotics like vancomycin and ciprofloxacin.
Area of Science:
- Biomaterials Science
- Ceramic Engineering
- Drug Delivery Systems
Background:
- Brushite cements require significant water for setting, unlike apatite-forming cements.
- Water-consuming cements theoretically enable near-zero porosity ceramics.
- Calcium phosphate cements often exhibit burst release of incorporated antibiotics.
Purpose of the Study:
- To produce a brushite ceramic with near-zero porosity.
- To investigate if reduced porosity mitigates antibiotic burst release.
- To optimize brushite cement properties for enhanced mechanical strength and controlled drug delivery.
Main Methods:
- Adjusted powder particle size and distribution.
- Optimized citric acid concentration in the liquid phase to 800mM.
- Incorporated vancomycin and ciprofloxacin up to 2wt.%.
Main Results:
- Achieved a brushite cement matrix with 11% relative porosity (60% reduction).
- Obtained a wet unprecompacted compressive strength of 52MPa (>100% increase).
- Demonstrated controlled, near-linear release of antibiotics, minimizing burst release.
Conclusions:
- Near-zero porosity brushite ceramics can be produced by controlling powder properties and liquid phase composition.
- Reduced porosity effectively minimizes burst release of incorporated antibiotics.
- Antibiotic solubility is a key factor influencing release profiles alongside cement porosity.
