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Conditional gene genealogies under strong purifying selection.

John Wakeley1

  • 1Department of Organismic and Evolutionary Biology, Harvard University, USA. wakeley@fas.harvard.edu

Molecular Biology and Evolution
|September 19, 2008
PubMed
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Strong selection significantly alters gene genealogies, deviating from neutral predictions when multiple unfavorable alleles are present. These findings extend selective sweep concepts to deleterious alleles, impacting human disease genetics.

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Genomics

Background:

  • Understanding gene genealogies is crucial for inferring evolutionary history.
  • Strong selection can deviate gene genealogies from neutral expectations.

Purpose of the Study:

  • To investigate gene genealogical processes under strong selection.
  • To analyze deviations from neutral predictions in two-allele systems.

Main Methods:

  • Utilized the ancestral selection graph model.
  • Conditioned on allelic types within samples.
  • Employed simulations to validate analytical predictions.

Main Results:

  • Neutral gene genealogies are predicted for random samples or those with one unfavorable allele.

Related Experiment Videos

  • Multiple unfavorable alleles lead to significant deviations from neutral predictions.
  • Gene genealogies under strong selection relate to neutral ones via the Ewens sampling formula.

    • Conclusions:

    • Strong selection, especially with deleterious alleles, profoundly impacts gene genealogies.
    • Results extend the soft selective sweep concept to unfavorable alleles.
    • Implications for interpreting polymorphism in human disease-causing alleles.