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Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...

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Related Experiment Video

Updated: Jun 30, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

Sensing necrosis with Mincle.

Gordon D Brown1

  • 1Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences, Division of Immunology, University of Cape Town, Observatory 7925, Cape Town, South Africa. gordon.brown@mweb.co.za

Nature Immunology
|September 19, 2008
PubMed
Summary
This summary is machine-generated.

Inflammation following necrotic cell death is not well understood. New research reveals that the C-type lectin Mincle plays a key role in this inflammatory process.

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Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis
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Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis

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Related Experiment Videos

Last Updated: Jun 30, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis
05:30

Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis

Published on: November 14, 2025

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Background:

  • Necrotic cell death triggers inflammatory responses, but the underlying molecular mechanisms remain largely unknown.
  • Understanding these pathways is crucial for developing targeted therapies for inflammatory diseases.

Discussion:

  • This study identifies Mincle (C-type lectin) as a novel mediator of inflammation subsequent to necrotic cell death.
  • Mincle's involvement suggests a new regulatory axis in sterile inflammation.

Key Insights:

  • The C-type lectin Mincle is implicated in the inflammatory cascade initiated by necrotic cell death.
  • This finding provides a new molecular target for modulating post-necrotic inflammation.

Outlook:

  • Further research will elucidate the precise signaling pathways involving Mincle in necrotic inflammation.
  • Targeting Mincle may offer therapeutic strategies for inflammatory conditions driven by cell death.