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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Kernel stick-breaking processes
1Biostatistics Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709, U.S.A. dunson1@niehs.nih.gov.
Abstract:
We propose a class of kernel stick-breaking processes for uncountable collections of dependent random probability measures. The process is constructed by first introducing an infinite sequence of random locations. Independent random probability measures and beta-distributed random weights are assigned to each location. Predictor-dependent random probability measures are then constructed by mixing over the locations, with stick-breaking probabilities expressed as a kernel multiplied by the beta weights. Some theoretical properties of the process are described, including a covariate-dependent prediction rule. A retrospective Markov chain Monte Carlo algorithm is developed for posterior computation, and the methods are illustrated using a simulated example and an epidemiological application.
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