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Primary cutaneous B-cell lymphoma in a child
Tania Condarco1, Elizabeth Sagatys, Amy V Prakash
1College of Medicine, University of South Florida, Tampa, Florida, USA.
Fetal and Pediatric Pathology
|September 19, 2008
Summary
This report details the first known case of primary cutaneous B-cell lymphoma of the follicle-center subtype in an 8-year-old child. The diagnosis was confirmed through histological and immunohistochemical analysis of a scalp nodule.
Area of Science:
- Dermatology
- Oncology
- Pediatric Pathology
Background:
- Primary cutaneous B-cell lymphoma (PCBCL) is a type of non-Hodgkin lymphoma confined to the skin.
- PCBCL lacks evidence of extracutaneous disease at diagnosis.
- Follicle-center lymphoma is a common subtype of B-cell lymphoma.
Observation:
- An 8-year-old boy presented with a solitary, firm, alopecic nodule on his right frontal scalp.
- Histopathological examination showed a mid-to deep-dermal mononuclear infiltrate.
- Immunohistochemistry revealed a B-cell population positive for CD10 and CD21, but negative for CD5 and bcl2.
Findings:
- The immunohistochemical profile (CD10+, CD5-, CD21+, bcl2-) is characteristic of the follicle-center subtype of PCBCL.
- This represents the first documented instance of this specific subtype of cutaneous lymphoma in a pediatric patient.
- The lesion was confined to the skin, meeting the criteria for primary cutaneous lymphoma.
Implications:
- This case expands the known age range for primary cutaneous B-cell lymphoma of the follicle-center subtype.
- Highlights the importance of considering rare cutaneous lymphomas in pediatric differential diagnoses.
- Contributes to the understanding of the clinical and pathological spectrum of pediatric lymphomas.
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