Related Experiment Video
Updated: Jun 30, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
[Galantamine therapy in dementia associated with CADASIL]
I J Posada1, M Ferrero, E Lopez-Valdes
1Servicio de Neurología, Hospital Universitario 12 de Octubre, Avda Córdoba, s/n E-28041, Madrid, Spain. iposada.hdoc@salud.madrid.org
Introduction:
Cholinergic neuronal impairment has been suggested in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencefalopathy (CADASIL). Cholinomimetic therapy could be useful.
Case Reports:
Four patients with CADASIL and dementia were treated with the acetylcholinesterase inhibitor galantamine and we assessed cognitive, behavioral, functional and the caregiver burden aspects. Three patients showed either mild improvement or stabilization in the behavior and caregiver burden.
Conclusion:
Our results suggest some benefit from galantamine treatment and they could support the existence of a cholinergic deficit in CADASIL.
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