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Polymorphism and solvatomorphism 2007.

Harry G Brittain¹

¹Center for Pharmaceutical Physics, 10 Charles Road, Milford, New Jersey 08848, USA. hbrittain@centerpharmphysics.com

Journal of Pharmaceutical Sciences

|September 23, 2008

Summary

This review summarizes 2007 research on polymorphism and solvatomorphism, covering crystal structures with identical or solvent-included elemental compositions. It highlights computational, preparative, and characterization studies of these solid forms.

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Area of Science:

Solid-state chemistry
Crystallography
Materials science

Background:

Polymorphism involves different crystal structures of the same compound.
Solvatomorphism includes solvent molecules within crystal structures.
Understanding these phenomena is crucial for material properties and drug development.

Purpose of the Study:

To provide a comprehensive overview of 2007 literature on polymorphism and solvatomorphism.
To consolidate research findings from major scientific journals and patents.
To track advancements in the study and application of crystalline solid forms.

Main Methods:

Literature review of papers and patents published in 2007.
Categorization of research into thematic sections.
Synthesis of information from physical, crystallographic, and pharmaceutical fields.

Main Results:

The review covers general interest articles, computational studies, and preparative methods.
Structural characterization, properties, and phase transformations of polymorphic and solvatomorphic systems are detailed.
Effects of secondary processing and relevant US patents from 2007 are included.

Conclusions:

The annual review serves as a vital resource for researchers in solid-state chemistry.
It highlights the breadth of research in polymorphism and solvatomorphism.
The findings underscore the importance of studying crystalline forms for various scientific disciplines.