Related Experiment Video
Updated: Jun 30, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and NMR elucidation of novel penta-cycloundecane amine derivatives as potential antituberculosis agents
Oluseye K Onajole1, Thavendran Govender, Maya Makatini
1School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa.
Abstract:
The synthesis and NMR elucidation of five novel penta-cycloundecane amine derivatives are reported. These compounds are potential antituberculosis agents. The (1)H and (13)C spectra showed major overlapping of methine signals of the cage skeleton making it extremely difficult to elucidate these compounds. The overlapping occurs as a result of the additions made to the carbonyl carbon (C-8/C-11) of the cage. The two-dimensional NMR technique proved to be a useful tool in overcoming this problem. All compounds reported are meso compounds thereby not only simplifying the NMR structure elucidation, but also making it indeed possible.
Related Concept Videos
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR
Aromatic Hydrocarbon Anions: Structural Overview
Due to the absence of continuous overlap of p...
Nomenclature of Primary Amines
Criteria for Aromaticity and the Hückel 4n + 2 Rule
For the first time, Eric Hückel, a German chemical physicist, derived a set of structural features for a compound to be classified as aromatic. This is now known as Hückel’s rule or the 4n + 2 rule.
Nomenclature of Aryl and Heterocyclic Amines
