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Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Related Experiment Video

Updated: Jun 30, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

Key biological issues in contact lens development.

Seana M McGlinchey¹, Colin P McCoy, Sean P Gorman

¹Queens University Belfast, Medical Devices Group, School of Pharmacy, Belfast, UK. smcglinchey04@qub.ac.uk

Expert Review of Medical Devices

|September 23, 2008

Summary

This summary is machine-generated.

Contact lens materials are evolving to improve comfort and reduce risks like microbial keratitis (MK). New materials aim to prevent bacterial adhesion and corneal infection, addressing a significant public health concern for contact lens wearers.

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Last Updated: Jun 30, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization

Published on: January 19, 2024

Area of Science:

Ophthalmology
Biomaterials Science
Microbiology

Background:

Contact lenses are widely used for vision correction, replacing spectacles.
Advancements in polymeric biomaterials enhance contact lens comfort and safety.
Microbial keratitis (MK), a serious eye infection, is a primary complication of contact lens wear, especially extended wear of hydrogel lenses.

Purpose of the Study:

To review the development of contact lens materials.
To understand the mechanisms of microbial keratitis (MK) development.
To explore novel strategies for preventing bacterial adhesion to contact lenses.

Main Methods:

Literature review on contact lens materials and microbial keratitis.
Analysis of factors influencing bacterial binding to contact lens surfaces.
Examination of the role of corneal hypoxia and damage in MK pathogenesis.

Main Results:

Bacterial adhesion to contact lens material precedes MK development.
Material properties and bacterial characteristics influence adhesion.
Corneal damage, often from trauma or hypoxia, is necessary for bacterial infiltration.
Newer materials aim to reduce corneal hypoxia during continuous wear.

Conclusions:

Preventing bacterial adhesion to contact lenses is crucial for limiting MK.
Continuous wear lenses with reduced hypoxia may decrease MK risk.
Novel approaches are needed to overcome limitations in current MK treatment and prevention.