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A heterospecific leucine zipper tetramer

Yiqun Deng1, Jie Liu, Qi Zheng

  • 1Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

Chemistry & Biology
|September 23, 2008
PubMed
Summary

Two GCN4 leucine zipper mutants form specific antiparallel, heterotetrameric structures. This coiled-coil recognition is driven by shape and chemistry complementarity at hydrophobic interfaces, revealing principles of molecular recognition.

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