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Published on: October 24, 2025
Anti-Müllerian hormone and ovarian dysfunction
Frank J Broekmans1, Jenny A Visser, Joop S E Laven
1Department for Reproductive Medicine and Gynecology, University Medical Center, PO Box 85500, 3508 6A, Utrecht, The Netherlands. f.broekmans@umcutrecht.nl
Trends in Endocrinology and Metabolism: TEM
|September 23, 2008
Summary
Anti-Müllerian hormone (AMH) is key for ovarian function and follicle development, correlating with follicle count. Elevated AMH levels are seen in PCOS, suggesting its diagnostic and management potential.
Area of Science:
- Reproductive endocrinology
- Gynecology
- Infertility research
Background:
- Anti-Müllerian hormone (AMH) is produced by ovarian granulosa cells.
- AMH plays a crucial role in postnatal ovarian function, including initial follicle development.
- Serum AMH levels correlate with the total number of ovarian follicles.
Purpose of the Study:
- To explore the significance of AMH in ovarian function and its clinical applications.
- To investigate the role of AMH in polycystic ovary syndrome (PCOS).
- To assess AMH as a marker for ovarian reserve in subfertile women.
Main Methods:
- Correlation analysis of serum AMH levels with ovarian follicle number.
- Observation of AMH levels in patients with PCOS.
- Evaluation of AMH as a clinical marker for ovarian reserve.
Main Results:
- Serum AMH levels correlate positively with ovarian follicle number.
- AMH levels are elevated in patients with polycystic ovary syndrome (PCOS).
- AMH is a useful marker for assessing ovarian reserve, particularly in cases of age-related subfertility.
Conclusions:
- AMH is vital for ovarian function and follicle development.
- AMH has potential relevance in the diagnosis and management of PCOS.
- AMH serves as a valuable clinical marker for ovarian reserve and may be a target for future reproductive technologies.
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