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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...

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Related Experiment Video

Updated: Jun 30, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Gateways to clinical trials.

A Tomillero1, M A Moral

  • 1Prous Science, S.A.U., Barcelona, Spain.

Methods and Findings in Experimental and Clinical Pharmacology
|September 23, 2008
PubMed
Summary
This summary is machine-generated.

This study reviews a comprehensive list of novel therapeutic agents, including small molecules, biologics, and vaccines, for various diseases. It highlights advancements in drug development and potential treatments across diverse medical fields.

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In Silico Clinical Trials for Cardiovascular Disease
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In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Area of Science:

  • Pharmacology and Therapeutics
  • Drug Discovery and Development
  • Biotechnology

Context:

  • The landscape of pharmaceutical research is rapidly evolving with the introduction of novel therapeutic agents.
  • Identifying and categorizing these agents is crucial for understanding current research trends and future directions.
  • This abstract encompasses a wide array of compounds, including small molecules, biologics, vaccines, and drug-device combinations.

Purpose:

  • To provide a consolidated overview of recently developed therapeutic agents.
  • To serve as a reference for researchers, clinicians, and industry professionals.
  • To facilitate discovery and understanding of potential treatments for various medical conditions.

Summary:

  • The abstract lists numerous therapeutic agents, such as Abatacept, Adalimumab, Aripiprazole, Bevacizumab, Bortezomib, Denosumab, Erlotinib hydrochloride, Everolimus, Gefitinib, Ipilimumab, Omalizumab, Paclitaxel nanoparticles, Pegfilgrastim, Pemetrexed disodium, Prasugrel, Pregabalin, Rivaroxaban, Sorafenib, Sunitinib malate, Temsirolimus, Tocilizumab, Tremelimumab, Varenicline tartrate, and Zotarolimus-eluting stent.
  • It includes small molecules like (+)-Dapoxetine hydrochloride, (R)-Etodolac, Alvocidib hydrochloride, Aminolevulinic acid methyl ester, Azacitidine, Becatecarin, Bevirimat, Bremelanotide, Canfosfamide hydrochloride, Ciclesonide, Clevidipine, Decitabine, Degarelix acetate, Desloratadine, DMXB-Anabaseine, Duloxetine hydrochloride, Dutasteride, Eletriptan, Enzastaurin hydrochloride, Escitalopram oxalate, Etoricoxib, Ezetimibe, Fesoterodine fumarate, Fulvestrant, Iclaprim, Laropiprant, Lumiracoxib, Mirabegron, Olmesartan medoxomil, Paliperidone, Pimecrolimus, Rimonabant, Rosuvastatin calcium, Satraplatin, Silodosin, Talarozole, Tolevamer potassium sodium, Valsartan/amlodipine besylate, Vardenafil hydrochloride hydrate, Varespladib, Voclosporin.
  • Biologics and vaccines mentioned include ABT-510, Agatolimod sodium, Alemtuzumab, AS01B, AS02B, AS02V, CAIV-T, CHR-2797, Darbepoetin alfa, Dendritic cell-based vaccine, Ecogramostim, Eicosapentaenoic acid/docosahexaenoic acid, Ferumoxytol, GM-CSF DNA, GSK-690693, H5N1 avian flu vaccine, Hepatitis B hyperimmunoglobulin, Human Fibroblast Growth Factor 1, Hypericin-PVP, Immunoglobulin intravenous (human), ISS-1018, L19-IL-2, Lapuleucel-T, Liposomal doxorubicin, LP-261, LY-518674, MDV-3100, MGCD-0103, MyoCell, NASHA/Dx, Niacin/laropiprant, O6-Benzylguanine, Ocrelizumab, P-276-00, Padoporfin, PAN-811, Pegaptanib octasodium, PF-00299804, Reolysin, SCH-697243, Selenite sodium, Taxus, TTP-889, Uracil, V-260, Vitespen, VX-001, Xience V.

Impact:

  • Provides a comprehensive catalog of emerging therapeutic agents for researchers and drug developers.
  • Facilitates the identification of potential drug candidates and therapeutic strategies.
  • Supports advancements in personalized medicine and treatment of complex diseases.