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Related Experiment Video

Updated: Jun 30, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

[Methods to increase the encapsulation efficiency for liposomal drugs].

Nóra Kaszás¹, Marianna Budai, Lívia Budai

¹Semmelweis Egyetem, Gyógyszerészeti Intézet, Budapest, Hogyes Endre utca 7. H-1092.

Acta Pharmaceutica Hungarica

|September 24, 2008

Summary

Liposomes enhance fluoroquinolone antibiotic delivery, improving efficacy against intracellular bacteria. Optimizing liposome formulation, including lipid composition and cholesterol, is key for efficient drug encapsulation and reduced side effects.

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Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Nanomedicine

Background:

Liposomes offer targeted drug delivery, reducing side effects compared to traditional forms.
Liposomal encapsulation can enhance the therapeutic efficacy of fluoroquinolone antibiotics like lomefloxacin against intracellular bacteria.

Purpose of the Study:

To investigate factors influencing lomefloxacin encapsulation efficiency in liposomes.
To optimize liposome formulation for improved drug delivery.

Main Methods:

Preparation of lomefloxacin-containing multilamellar vesicles using various lipids and hydrating solutions.
Evaluation of lipid composition, cholesterol content, and liposome surface charge effects on encapsulation efficiency.

Main Results:

Lipid composition significantly impacts lomefloxacin encapsulation.
Cholesterol content and surface charge play crucial roles in drug loading.
Optimized formulations demonstrated enhanced encapsulation efficiency.

Conclusions:

Rational design of liposomes can improve fluoroquinolone antibiotic delivery.
Findings contribute to developing effective liposomal drug formulations for intracellular infections.