[Neonatal bronchopulmonary dysplasia: morphogenesis, morphological diagnosis]

Four groups of changes (premorbid, paradysplastic, nonspecific, and pathognomonic) have been detected in the lung of 64 dead children w ith neonatal bronchopulmonary dysplasia (NBPD) on artificial ventilation (AV) for an average of 20 +/- 0.1 days. In the latter group, the authors have identified the key structures that reflect the pathogenetic action of aggressive factors of AV and that are diagnostic markers of the 4 detected stages of NBPD morphogenesis: bronchiolectasis and stellar atelectasis (Stage 1); rosette-like bronchioli (Stage 2); mosaic pneumosclerosis and fibroatelectases (stellate, moire, and fibromuscular) (Stage 3); and honeycomb lung (Stage 4).