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Risk factors of morbidity and mortality in patients with perforated peptic ulcer

G Bas1, R Eryilmaz, I Okan

  • 1Department of Surgery, Vakif Gureba Training and Research Hospital, Istanbul, Turkey. gurhanbas@yahoo.com

Acta Chirurgica Belgica
|September 24, 2008
PubMed

Insights

Advanced age and delayed treatment significantly increase the risk of complications and mortality in patients with perforated peptic ulcer (PPU). Early diagnosis and intervention are crucial for better outcomes.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Clinical Medicine

Background:

  • Peptic ulcer perforation (PPU) presents a significant clinical challenge.
  • High rates of morbidity and mortality are associated with PPU.
  • Identifying peri-operative risk factors is essential for improving patient outcomes.

Purpose of the Study:

  • To prospectively evaluate complications in patients with PPU.
  • To identify risk factors associated with peri-operative morbidity and mortality in PPU patients.

Main Methods:

  • A prospective clinical study involving 97 patients hospitalized for PPU.
  • Data collected included patient demographics, co-morbidities, and treatment details.
  • Multivariate logistic regression analysis was employed to identify significant risk factors.

Main Results:

  • The overall morbidity rate was 15.5% and the mortality rate was 5.2%.
  • Advanced age and delayed admission were significantly linked to increased morbidity (p < 0.006 and p < 0.001, respectively).
  • Mortality showed a trend towards association with advanced age, therapeutic delay, and co-morbidities.

Conclusions:

  • Patient age and therapeutic delay are key predictors of outcomes following PPU surgery.
  • Minimizing diagnostic and treatment delays, particularly in elderly patients, can reduce morbidity and mortality.
  • Effective management of co-existing medical conditions is vital for improving PPU patient care.
Abstract

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