[Multiple sclerosis and familial Mediterranean fever: a case report]

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A Guinet1, G Grateau, C Nifle

  • 1Service de neurologie, centre hospitalier de Versailles, hôpital André-Mignot, 1, rue Richaud, 78000 Versailles, France.

Revue Neurologique
|September 24, 2008
PubMed
Abstract

Insights

This case report details a patient with Familial Mediterranean Fever (FMF) and Multiple Sclerosis (MS), highlighting rare neurological complications and the importance of differentiating from neuro-Behçet disease.

Area of Science:

  • Neurology
  • Rheumatology
  • Immunology

Background:

  • Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder.
  • Central nervous system (CNS) involvement is uncommon in FMF patients.
  • The co-occurrence of FMF and Multiple Sclerosis (MS) is rarely documented.

Observation:

  • A 37-year-old male with a history of FMF since age 17, treated with colchicine, presented with neurological symptoms.
  • The patient experienced diplopia and leg numbness, followed by recurrent neurological events consistent with MS.
  • Investigations for neuro-Behçet disease were negative despite aphthous ulcer development.

Findings:

  • The case highlights a patient with both FMF and MS, presenting with neurological manifestations.
  • The diagnostic process involved ruling out neuro-Behçet disease, a crucial differential diagnosis in FMF patients with neurological disorders.
  • Current treatment for both FMF and MS remained unchanged based on the clinical presentation.

Implications:

  • This case contributes to the limited literature on the association between FMF and MS.
  • It underscores the importance of a thorough differential diagnosis for neurological symptoms in FMF patients.
  • Further research is needed to clarify whether the co-occurrence of FMF and MS is coincidental or represents a true association.

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