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Related Concept Videos

What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...

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Related Experiment Video

Updated: Jun 30, 2026

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform
09:13

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform

Published on: January 13, 2016

Mapping the gene expression universe.

Eric Lécuyer1, Pavel Tomancak

  • 1Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario, Canada. eric.lecuyer@utoronto.ca

Current Opinion in Genetics & Development
|September 24, 2008
PubMed
Summary
This summary is machine-generated.

Gene expression atlases map gene activity during development using advanced imaging and computer vision. These tools will revolutionize comparative genomics and developmental biology research.

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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
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Last Updated: Jun 30, 2026

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform
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Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform

Published on: January 13, 2016

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
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Area of Science:

  • Developmental Biology
  • Genomics
  • Bioinformatics

Background:

  • Global gene expression surveys offer insights into developmental gene function.
  • In situ hybridization reveals diverse gene expression patterns.
  • New imaging technologies enhance resolution at multiple biological levels.

Purpose of the Study:

  • To explore the potential of computer vision in analyzing large-scale gene expression datasets.
  • To outline the future of genome-wide atlases for studying developmental processes.

Main Methods:

  • Utilizing advanced imaging techniques for high-resolution gene expression pattern capture.
  • Applying computer vision for pattern recognition in massive annotated image databases.
  • Developing genome-wide atlases to record gene activity in vivo.

Main Results:

  • Gene expression patterns are highly diverse across developmental stages.
  • Computer vision facilitates the analysis of complex imaging data.
  • High-resolution atlases will provide unprecedented insights into gene function.

Conclusions:

  • Genome-wide atlases with cellular resolution will significantly advance comparative genomics.
  • These datasets will revolutionize the deciphering and modeling of developmental processes.
  • Integration of imaging and computational approaches is key for future discoveries.