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Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF
Sarah Robinson1, Phil Pemberton, Ian Laing
1Department of Clinical Biochemistry, Manchester Royal Infirmary, Manchester, UK.
Purpose:
To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, and IVF outcome.
Methods:
We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI < 30 kg/m(2) with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 and 10, number of oocytes collected, number of oocytes fertilised and pregnancy outcome were recorded.
Results:
Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r = 0.386, P < .001) but not to age and smoking habit. There were no significant relationships between basal hs-CRP and any of the measured IVF outcomes.
Conclusions:
These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle or pregnancy outcome in women undergoing IVF treatment.
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