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C-reactive protein and coronary calcium score association in coronary artery disease

Ali Hosseinsabet1, Ahmad Mohebbi, Alireza Almasi

  • 1Department of Cardiology, Shaheed Rajaei Cardiovascular Center, Vali-e-asr Avenue, Tehran, Iran. ali_hosseinsabet@yahoo.com

Cardiology Journal
|September 24, 2008
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) does not correlate with coronary artery calcium score (CCS), suggesting inflammation markers and atherosclerosis indices offer distinct cardiovascular risk insights.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • High-sensitivity C-reactive protein (hs-CRP) and coronary artery calcium score (CCS) are established cardiovascular risk markers.
  • The relationship between hs-CRP, atherosclerotic burden, and acute coronary events remains unclear.

Purpose of the Study:

  • To investigate the association between hs-CRP and CCS in patients undergoing coronary artery bypass grafting (CABG).
  • To determine if hs-CRP reflects atherosclerotic burden or predicts acute coronary events.

Main Methods:

  • Cross-sectional study of 143 patients considered for CABG.
  • Bivariate and multivariate analyses were performed to assess the relationship between hs-CRP and CCS.
  • Subgroup analysis was conducted on patients not using statins.

Main Results:

  • No significant association was found between hs-CRP and CCS in the overall patient group (bivariate p=0.162, multivariate p=0.062).
  • In patients not using statins, a positive association was observed in bivariate analysis (p=0.001) and a negative association in multivariate analysis (p=0.008).

Conclusions:

  • hs-CRP is not correlated with CCS, indicating they provide distinct cardiovascular risk information.
  • Inflammation markers (hs-CRP) and atherosclerosis indices (CCS) likely offer complementary data for risk assessment.
  • The link between CRP and clinical events may not be directly tied to the extent of atherosclerotic burden.
Abstract

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