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Crohn's disease--defect in innate defence

Michael Gersemann1, Jan Wehkamp, Klaus Fellermann

  • 1Internal Medicine I, Robert Bosch Hospital, Auerbachstrasse 110, Stuttgart, Germany.

World Journal of Gastroenterology
|September 24, 2008
PubMed
Summary

Crohn's disease involves defects in the gut's innate immune system, specifically the antimicrobial barrier. This leads to reduced alpha- and beta-defensins, allowing microbes to trigger inflammation in the ileum and colon.

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