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Updated: Jun 30, 2026
Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Evaluation of lipoxygenase inhibitory activity of anacardic acids
Isao Kubo1, Tae Joung Ha, Kazuo Tsujimoto
1Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3114, USA. ikubo@calmail.berkeley.edu
Abstract:
6-Alkylsalicylic acids inhibit the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) competitively and without pro-oxidant effects. This activity is largely dependent on the nature of their alkyl side chains. Inhibitory activities of anacardic acids, viz. 6-pentadec(en)ylsalicylic acids, isolated from the cashew Anacardium occidentale, were initially used for comparison because their aromatic head portions are the same. Consequently, the data should be interpreted to mean that changes in the hydrophobic side chain tail portions of the molecules evaluated correlate with the specific activity determined.
