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Published on: July 22, 2012

The clinical features of infantile gastroenteritis due to rotavirus

M E Carr, G D McKendrick, T Spyridakis

    Scandinavian Journal of Infectious Diseases
    |January 1, 1976
    PubMed

    Insights

    Rotavirus infantile gastroenteritis in 100 infants often presented with fever and diarrhea. Co-infection with coliforms prolonged illness, suggesting rotavirus may precede coliform gastroenteritis.

    Area of Science:

    • Pediatrics
    • Virology
    • Infectious Diseases

    Background:

    • Infantile gastroenteritis is a common and significant health concern in infants.
    • Rotavirus is a primary cause of severe diarrheal disease globally.
    • Understanding the clinical presentation and contributing factors is crucial for effective management.

    Purpose of the Study:

    • To describe the clinical symptoms and course of rotavirus infantile gastroenteritis in hospitalized infants.
    • To investigate potential correlations between clinical parameters and viral load.
    • To explore the role of co-infections, specifically enteropathic coliforms, in disease severity and duration.

    Main Methods:

    • Retrospective analysis of 100 hospitalized infant cases with confirmed rotavirus gastroenteritis.
    • Detailed recording of presenting symptoms including fever, diarrhea, vomiting, and upper respiratory tract involvement.
    • Assessment of electrolyte disturbances and blood urea levels.
    • Evaluation of illness duration in uncomplicated cases and those with co-infections.

    Main Results:

    • Most infants presented with high fever (2nd-5th day), diarrhea, and/or vomiting.
    • 42% of infants exhibited upper respiratory tract symptoms.
    • Severe electrolyte disturbances were uncommon; higher blood urea showed a possible correlation with rotavirus particle count.
    • Mean duration for uncomplicated cases was 13.4 days.
    • Co-infection with enteropathic coliforms extended the illness duration to 23 days.

    Conclusions:

    • Rotavirus gastroenteritis in infants is characterized by fever, gastrointestinal, and sometimes respiratory symptoms.
    • While severe electrolyte issues were rare, blood urea may correlate with viral load.
    • Enteropathic coliform co-infection significantly worsens the prognosis, prolonging illness duration.
    • Rotavirus infection may act as a precursor for subsequent coliform gastroenteritis.

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