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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: Jun 30, 2026

Enrichment of Bruch's Membrane from Human Donor Eyes

Enrichment of Bruch's Membrane from Human Donor Eyes

Published on: November 15, 2015

Macular amyloidosis: a case report.

Jaka Rados¹, Sandra Marinović Kulisić, Jasna Lipozencić

¹University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, Salata 4, Zagreb, Croatia. sodarakaj@yahoo.com

Acta Dermatovenerologica Croatica : ADC

|September 25, 2008

Summary

This summary is machine-generated.

Macular amyloidosis, a skin pigmentation disorder, is often linked to chronic friction. While tretinoin therapy eased itching in a patient, hyperpigmentation persisted, suggesting limited treatment efficacy for this condition.

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Area of Science:

Dermatology
Histopathology
Clinical Medicine

Background:

Macular amyloidosis is a rare cutaneous condition causing skin pigmentation, more prevalent in Asia and South America than in Western countries.
Its exact cause is unclear, but chronic friction is a significant suspected risk factor.
This case study focuses on a patient diagnosed with macular amyloidosis in Croatia.

Observation:

A 54-year-old patient presented with persistent grayish-brown pigmentation on the scapula, localized itching, and a compulsive scratching urge.
Diagnostic confirmation involved patient history and histological examination revealing amyloid deposits.
The patient underwent a three-month treatment with tretinoin.

Findings:

Tretinoin therapy led to significant alleviation of pruritus (itching).
However, the hyperpigmentation on the scapula showed no improvement after the three-month treatment period.
This suggests that while tretinoin may manage symptoms like itching, it does not resolve the visible skin changes.

Implications:

The case highlights the diagnostic criteria for macular amyloidosis, including clinical presentation and histological evidence.
It underscores the limited effectiveness of current therapies like tretinoin in reversing the characteristic hyperpigmentation.
Further research is needed to clarify the pathogenesis and explore more effective treatment strategies for macular amyloidosis, as its prevalence may be underestimated in regions like Croatia.