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Published on: May 14, 2020
Ratio of lethal and edema factors in rabbit systemic anthrax
Federica Dal Molin1, Antonio Fasanella, Morena Simonato
1Dipartimento di Scienze Biomediche- CNR Istituto di Neuroscienze, viale G. Colombo 3, 35121 Padova, Italy.
Abstract:
Bacillus anthracis secretes two binary toxins: lethal toxin (PA + LF) and edema toxin (PA + EF) that play a major role in the pathogenesis of anthrax. Their activities can synergize or interfere among each other, depending on the cell type. It is therefore fundamental to know their concentration ratio in vivo. Here, we report the first determination of the concentration ratio of anthrax toxin components LF/EF in the serum of rabbits infected with B. anthracis spores.

