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Magnetic resonance diffusion/perfusion phantom experiments.

C H Lorenz1, D R Pickens, D B Puffer

  • 1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37203.

Magnetic Resonance in Medicine
|June 1, 1991
PubMed
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Phantom studies evaluated magnetic resonance imaging models for microcirculation, focusing on the intravoxel incoherent motion (IVIM) model. This research assessed model assumptions and sensitivity to perfusion changes for improved physiological system application.

Area of Science:

  • Magnetic Resonance Imaging
  • Physiology
  • Medical Imaging

Background:

  • Several magnetic resonance imaging (MRI) models, including intravoxel incoherent motion (IVIM), intravoxel coherent motion (IVCM), and tracer models, have been proposed for microcirculatory parameter determination.
  • Evaluating these models in controlled phantom studies is crucial before applying them to complex physiological systems.

Purpose of the Study:

  • To assess the assumptions, measurement uncertainties, and sensitivity to perfusion changes of microcirculatory MRI models.
  • To emphasize the evaluation of the intravoxel incoherent motion (IVIM) model while presenting techniques applicable to other models.
  • To provide guidance on pulse sequence development, phantom design, and data interpretation for model evaluation.

Main Methods:

  • Utilized a range of phantoms, from simple stationary fluid volumes to mechanically pumped phantoms, isolated animal kidneys, and in vivo animal models.

Related Experiment Videos

  • Developed and applied specific magnetic resonance imaging (MRI) pulse sequences tailored for microcirculatory assessments.
  • Employed phantom studies to systematically investigate model assumptions, quantify measurement uncertainties, and determine sensitivity to perfusion variations.

    • Main Results:

    • Phantom studies provided a robust assessment of the intravoxel incoherent motion (IVIM) model's performance and limitations.
    • Demonstrated the sensitivity of MRI-derived microcirculatory parameters to changes in perfusion across different phantom complexities.
    • Established a framework for evaluating the reliability and accuracy of various microcirculatory MRI models.

    Conclusions:

    • Phantom studies are essential for validating MRI models of microcirculation before in vivo application.
    • The intravoxel incoherent motion (IVIM) model and related techniques require careful consideration of pulse sequence design, phantom setup, and data interpretation for accurate physiological parameter estimation.
    • The presented methodologies can be extended to evaluate other advanced MRI models for microcirculatory research.