Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRecover: A Conditional Generative Model for Recovering Motion- Corrupted MR images Using AI Generated Contrast.

Research square·2026
Same author

Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Patterns of brain activation and hippocampal functional connectivity associated with verbal memory in midlife postmenopausal women.

Maturitas·2026
Same author

FairGen: preference-aligned diffusion for demographically equitable medical image synthesis.

NPJ digital medicine·2026
Same author

An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology.

bioRxiv : the preprint server for biology·2026
Same author

CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression.

medRxiv : the preprint server for health sciences·2026
Same journal

The role of sleep in strengthening face learning and memory consolidation: A systematic review.

Cognitive, affective & behavioral neuroscience·2026
Same journal

How the brain represents a romantic partner: Dissociable roles of the nucleus accumbens and anterior insula.

Cognitive, affective & behavioral neuroscience·2026
Same journal

Predictive processing in time perception: Assessing prediction error minimization in the sub-second range.

Cognitive, affective & behavioral neuroscience·2026
Same journal

When attention falters: Brain, breathing, and behavioral signals of lapses in interoceptive attention.

Cognitive, affective & behavioral neuroscience·2026
Same journal

Fronto-Parietal EEG asymmetry interactions predict negative attention bias: A secondary data analysis.

Cognitive, affective & behavioral neuroscience·2026
Same journal

Correction: The neural basis of cost-benefit trade-offs in effort investment: a quantitative activation likelihood estimation meta-analysis.

Cognitive, affective & behavioral neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2026

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Striatal outcome processing in healthy aging.

Karin M Cox1, Howard J Aizenstein, Julie A Fiez

  • 1Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. kmc51@pitt.edu

Cognitive, Affective & Behavioral Neuroscience
|September 26, 2008
PubMed
Summary
This summary is machine-generated.

Older adults

More Related Videos

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Related Experiment Videos

Last Updated: Jun 30, 2026

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Neuroimaging

Background:

  • The striatum is crucial for processing rewards and punishments in young adults.
  • Previous research on older adults focused on outcome anticipation, not delivered outcomes.

Purpose of the Study:

  • To investigate striatal responses to monetary rewards and punishments in older adults.
  • To compare age-related differences in striatal activity during outcome processing.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used.
  • A card-guessing task with monetary gains and losses was administered.
  • Participants included 20 older adults and 13 younger adults.

Main Results:

  • Older adults showed reliable striatal (caudate head) differentiation between rewards and punishments.
  • Reductions in the magnitude and extent of striatal activation were observed in older adults.
  • A trend towards a decreased early punishment response was noted in older adults.

Conclusions:

  • Striatal signaling of outcome valence is largely preserved in late adulthood.
  • Subtle age-related changes in striatal response magnitude and timing may occur.
  • Further research is needed to fully understand lifespan changes in outcome processing.