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Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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Published on: March 31, 2019

Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity.

Deborah J Good1, Christopher A Coyle, Dana L Fox

  • 1Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA. goodd@vt.edu

Exercise and Sport Sciences Reviews
|September 26, 2008
PubMed
Summary
This summary is machine-generated.

Nhlh2 gene deletion in mice causes obesity and less exercise. This suggests Nhlh2 (NHLH2 in humans) controls the ability or motivation for physical activity.

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Area of Science:

  • Neuroscience
  • Genetics
  • Metabolic research

Background:

  • The basic helix-loop-helix transcription factor Nhlh2 plays a role in regulating physiological processes.
  • Genetic modifications affecting Nhlh2 have been linked to metabolic dysregulation.

Purpose of the Study:

  • To investigate the role of Nhlh2 in regulating physical activity and energy balance.
  • To test the hypothesis that Nhlh2 transcriptional activity influences exercise capacity or motivation.

Main Methods:

  • Targeted deletion of the Nhlh2 gene in a mouse model.
  • Assessment of physical activity levels and body weight in Nhlh2-deficient mice.
  • Analysis of potential molecular mechanisms linking Nhlh2 to exercise behavior.

Main Results:

  • Mice with Nhlh2 deletion exhibited adult-onset obesity.
  • Nhlh2-deficient mice displayed significantly reduced physical activity levels.
  • These findings indicate a critical role for Nhlh2 in maintaining energy homeostasis and promoting physical activity.

Conclusions:

  • Transcriptional activity of Nhlh2 is essential for regulating physical activity and preventing obesity.
  • NHLH2 in humans may represent a potential therapeutic target for obesity and related metabolic disorders.
  • Further research is warranted to elucidate the precise neural pathways and molecular mechanisms through which Nhlh2 influences exercise behavior.